Intravenous vitamin C administration reduces fatigue in office workers

In this South Korean trial, 141 healthy office workers randomly received either 10 grams of IV vitamin C or a saline placebo, with neither participants nor researchers knowing who got which.

Two hours later, the vitamin C group reported lower fatigue scores, and the difference persisted at the one-day mark. Blood tests confirmed higher vitamin C levels and lower markers of oxidative stress in the treatment group.

When researchers split participants by baseline vitamin C status, only those who started low showed a significant fatigue benefit. People with adequate levels did not improve more than placebo.

The study tracked participants for just one day, so nothing is known about lasting effects. It is one of the stronger trials in IV vitamin research, and its own data suggest the benefit depends on whether you were deficient to begin with.